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Abeta decreases apical dendrite arborizations in cortical pyramidal cells in transgenic mice
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The study investigated the effects of elevated soluble Abeta on neuronal morphology in mutant human amyloid precursor protein (hAPP) transgenic mice somatosensory pyramidal cells. Basal arbors were unaffected, but apical arbors were shortened in total length and less branched. The diameter of proximal dendritic segments was increased whereas that of distal segments was reduced. There was a significant reduction in spine densities along the whole course of dendrites.
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Revisions: 6
Last Time: 11/21/2008 10:37:55 AM
Reviewer: Pradeep Mutalik
Owner: Pradeep Mutalik