Pathological mechanism

Data

Name Abeta decreases apical dendrite arborizations in cortical pyramidal cells in transgenic mice

Description

Hypothesis Dendritic hypothesis Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Reduces Show Other

Process Dendritic Arborization Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region Visual cortex Show Other

Neuron Neocortex L5/6 pyramidal GLU cell Show Other

Cell model

Cellular compartment Apical dendrite Show Other

PubMed ID 16781686

Citation

AlzWeb

Notes The study investigated the effects of elevated soluble Abeta on neuronal morphology in mutant human amyloid precursor protein (hAPP) transgenic mice somatosensory pyramidal cells. Basal arbors were unaffected, but apical arbors were shortened in total length and less branched. The diameter of proximal dendritic segments was increased whereas that of distal segments was reduced. There was a significant reduction in spine densities along the whole course of dendrites.

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim Pathological plaques and tangles in Alzheimer's are primarily in and around dendrites Show Other