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Data
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Nigral dopaminergic neurons: effects of ethanol on Ih (Migliore et al. 2008)
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We use a realistic computational model of dopaminergic neurons in vivo to suggest
that ethanol, through its effects on Ih, modifies the temporal structure of the spiking
activity. The model predicts that the dopamine level may increase much more during bursting
than pacemaking activity, especially in those brain regions with a slow dopamine clearance rate.
The results suggest that a selective pharmacological remedy could thus be devised against the
rewarding effects of ethanol that are postulated to mediate alcohol abuse and addiction,
targeting the specific HCN genes expressed in dopaminergic neurons.
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Substantia nigra pars compacta DA cell Show
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Migliore M, Cannia C, Canavier CC (2008) Show
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112359
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Migliore, Michele [Michele.Migliore at Yale.edu] Show
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299
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