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Pathological mechanism
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Abeta inhibits LTP both in soluble and fibrillar conformational states
Abeta1-40 peptide in soluble and fibrillar forms (beta pleated sheets) that are morphologically distinct can both attenuate hippocampal long-term potentiation (LTP) in the CA1 in vivo. The fibrillar form may also influence transmitter release.
Abeta1-40 peptide in soluble and fibrillar forms (beta pleated sheets) that are morphologically distinct can both attenuate hippocampal long-term potentiation (LTP) in the CA1 in vivo. The fibrillar form may also influence transmitter release.Schmid, A. W., Freir, D. B., & Herron, C. E. (2008). Inhibition of LTP in vivo by beta-amyloid peptide in different conformational states. Brain Res, 1197, 135-142.
Other categories referring to Abeta inhibits LTP both in soluble and fibrillar conformational states
Revisions: 4
Last Time: 7/31/2008 12:04:03 PM
Reviewer: Pradeep Mutalik
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