Pathological mechanism

Data

Name Picomolar concentrations of abeta monomers disrupt LTP

Description

Hypothesis

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Inhibits Show Other

Process LTP Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region

Neuron

Cell model

Cellular compartment

PubMed ID 18359102

Citation

AlzWeb

Notes Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior.Selkoe DJ. Behav Brain Res. 2008

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim