Pathological mechanism

Data

Name Abeta42/Abeta40 ratio correlates with impaired LTP in a mouse model of Alzheimers

Description

Hypothesis

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Inhibits Show Other

Process LTP Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region Hippocampus CA1 Show Other

Neuron

Cell model

Cellular compartment Dendrite Show Other

PubMed ID 16549764

Citation

AlzWeb

Notes Abeta42/Abeta40 ratio correlates with impaired LTP and with dendritic spine density and behavioral competence in the Tg2576 mouse model of AD. This happens before there is any significant increase in beta amyloid levels. Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease.Jacobsen JS, Wu CC, Redwine JM, Comery TA, Arias R, Bowlby M, Martone R, Morrison JH, Pangalos MN, Reinhart PH, Bloom FE. Proc Natl Acad Sci U S A. 2006 Mar 28, 103(13):5161-6.

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim