Pathological mechanism

Data

Name Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP

Description

Hypothesis LTP hypothesis Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Inhibits Show Other

Process LTP Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent Nicotine Show Other

Pharmacological Action Reverses Show Other

Brain region Hippocampus CA1 Show Other

Neuron

Cell model Brain slice preparations Show Other

Cellular compartment

PubMed ID 17610911

Citation

AlzWeb

Notes Welsby, P. J., Rowan, M. J., & Anwyl, R. (2007). Beta-Amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP. Neuropharmacology, 53(1), 188-195. Postulate that nicotine-enhanced LTP has certain different mechanisms to that of control LTP which results in a resistance to inhibition by Abeta.

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim