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Pathological mechanism
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Abeta oligomer inhibits p-21 activated kinase and stimulates ROCK signalling
Salminen, A., Suuronen, T., & Kaarniranta, K. (2008). ROCK, PAK, and toll of synapses in alzheimer's disease. Biochemical and Biophysical Research Communications, 2008 Jul 11;371(4):587-90. Brain tissue in AD recognizes the beta-amyloid peptide oligomers as foreign protein particles and mounts an inflammatory defense via Toll-like receptor (TLR) signaling which causes synaptic impairment. Synaptic dysfunction is a sensitive parameter of the AD pathology. Rho GTPases and the Rho kinases, ROCK1/2, and PAK1-3, are important regulators of synaptic plasticity, especially in maintaining the actin cytoskeleton of dendritic spines.
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Last Time: 10/27/2017 9:58:50 PM
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Owner: Pradeep Mutalik