Pathological mechanism

Data

Name Abeta oligomer causes aberrant activity of p-21 activated kinase

Description

Hypothesis Dendritic Spine Hypothesis Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element p-21 activated kinase (PAK) Show Other

Pathological action Disrupts Show Other

Process

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region Hippocampus CA1 Show Other

Neuron

Cell model

Cellular compartment

PubMed ID 18347024

Citation

AlzWeb

Notes Ma, Q. L., Yang, F., Calon, F., Ubeda, O. J., Hansen, J. E., Weisbart, R. H., et al. (2008). P21-Activated kinase aberrant activation and translocation in alzheimer's disease pathogenesis. J Biol Chem, , Defects in dendritic spines and synapses contribute to cognitive deficits in mental retardation syndromes and, potentially, Alzheimer disease. Results implicate aberrant PAK in Abeta oligomer-induced signaling and synaptic deficits in Alzheimer disease.

Pathology Alzheimer Show Other

Stage Late Show Other

Question Exclude - Biochemistry

Claim