Pathological mechanism

Data

Name Aging decreases NMDA receptors and increases GABA A-receptor mediated inhibition

Description

Hypothesis LTP hypothesis Show Other

Extracelular pathological element

Intracelular pathological element

Pathological action

Process Aging Show Other

Process action Decreases Show Other

Transmitter(s)

Receptor(s) NMDA Show Other

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region

Neuron

Cell model

Cellular compartment

PubMed ID 17465981

Citation

AlzWeb

Notes Dickstein, D. L., Kabaso, D., Rocher, A. B., Luebke, J. I., Wearne, S. L., & Hof, P. R. (2007). Changes in the structural complexity of the aged brain. Aging Cell, 6(3), 275-284. Age-related neuronal dysfunction, which must underlie observed decline in cognitive function, probably involves a host of other subtle changes within the cortex that could include alterations in receptors, loss of dendrites, and spines and myelin dystrophy, as well as the alterations in synaptic transmission.

Pathology Alzheimer Show Other

Stage Early Show Other

Question Excluded - No pathological Agent

Claim