Pathological mechanism

Data

Name Neurofibrillary tangles are correlated with spinophilin and with Alzheimer's cognitive decline

Description

Hypothesis Dendritic Spine Hypothesis Show Other

Extracelular pathological element

Intracelular pathological element Neurofibrillary tangles (NFT) Show Other

Pathological action Is Correlated with Show Other

Process Cognitive Decline in Alzheimer's Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region Hippocampus CA1 Show Other

Neuron

Cell model

Cellular compartment

PubMed ID 17420070

Citation

AlzWeb

Notes Akram, A., Christoffel, D., Rocher, A. B., Bouras, C., Kövari, E., Perl, D. P., et al. (2007). Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: Relationship with the progression of alzheimer's disease. Neurobiol Aging, , Spinophilin is a postsynaptic marker mainly located to the heads of dendritic spines. Data suggest that neocortical dendritic spine loss is an independent parameter to consider in AD clinicopathologic correlations.

Pathology Alzheimer Show Other

Stage Late Show Other

Question

Claim Loss/alteration of dendritic spines in early Alzheimer's Show Other