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Post-synaptic Drebrin correlated with Alzheimer's cognitive decline
  • Cognitive Decline in Alzheimer's Show Other
Kojima, N., & Shirao, T. (2007). Synaptic dysfunction and disruption of postsynaptic drebrin-actin complex: A study of neurological disorders accompanied by cognitive deficits. Neuroscience Research, 58(1), 1-5. The level of postsynaptic drebrin, a major F-actin-binding protein in dendritic spines, correlates well with the severity of cognitive impairment. We propose that an imbalanced regulation of the actin-regulatory machinery (loss of drebrin and increase of dephosphorylated cofilin) results in synaptic dysfunction, which underlies the cognitive impairment accompanying neurological disorders and normal aging.
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Last Time: 10/27/2017 9:55:10 PM
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Owner: Pradeep Mutalik