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Pathological mechanism
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Drebrin decrease in frontal cortex correlated with mild Alzheimer's disease
  • Cognitive Decline in Alzheimer's Show Other
Counts, S. E., Nadeem, M., Lad, S. P., Wuu, J., & Mufson, E. J. (2006). Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment. Journal of Neuropathology and Experimental Neurology, 65(6), 592-601. Levels of DRB, a dendritic spine plasticity marker, were reduced approximately 40% to 60% in all cortical regions in AD compared with normals.In contrast, DRB levels in the superior frontal cortex increased approximately 30% in AD subjects.
  • Loss/alteration of dendritic spines in early Alzheimer's Show Other
Other categories referring to Drebrin decrease in frontal cortex correlated with mild Alzheimer's disease
Revisions: 1
Last Time: 6/4/2008 11:51:13 AM
Reviewer: Pradeep Mutalik
Owner: Pradeep Mutalik