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Effect of slowly inactivating IKdr to delayed firing of action potentials (Wu et al. 2008)
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"The properties of slowly inactivating delayed-rectifier K+ current (IKdr) were investigated in NG108-15 neuronal cells differentiated with long-term exposure to dibutyryl cyclic AMP. ... The computer model, in which state-dependent inactivation of IKdr was incorporated, was also implemented to predict the firing behavior present in NG108-15 cells. ... Our theoretical work and the experimental results led us to propose a pivotal role of slowly inactivating IKdr in delayed firing of APs in NG108-15 cells. The results also suggest that aconitine modulation of IKdr gating is an important molecular mechanism through which it can contribute to neuronal firing."
  • Wu SN, Chen BS, Lin MW, Liu YC (2008) Show Other
snwu@mail.ncku.edu.tw
Sheng-Nan Wu, Bing-Shuo Chen
Wu SN, Chen BS, Lin MW, Liu YC. Contribution of slowly inactivating potassium current to delayed firing of action potentials in NG108-15 neuronal cells: Experimental and theoretical studies. J Theor Biol 2008;252:711-21
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Revisions: 8
Last Time: 6/6/2008 10:12:48 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin