|
Data
|
Effect of slowly inactivating IKdr to delayed firing of action potentials (Wu et al. 2008)
|
|
|
|
"The properties of slowly inactivating delayed-rectifier K+ current (IKdr) were investigated in NG108-15 neuronal cells differentiated with long-term exposure to dibutyryl cyclic AMP.
...
The computer model, in which state-dependent inactivation of IKdr was incorporated, was also implemented to predict the firing behavior present in NG108-15 cells.
...
Our theoretical work and the experimental results led us to propose a pivotal role of slowly inactivating IKdr in delayed firing of APs in NG108-15 cells. The results also suggest that aconitine modulation of IKdr gating is an important molecular mechanism through which it can contribute to neuronal firing."
|
|
|
|
|
|
|
|
-
Wu SN, Chen BS, Lin MW, Liu YC (2008) Show
Other
|
|
|
|
|
|
|
snwu@mail.ncku.edu.tw
|
|
|
|
|
|
|
|
|
Sheng-Nan Wu, Bing-Shuo Chen
|
|
Wu SN, Chen BS, Lin MW, Liu YC. Contribution of slowly inactivating potassium current to delayed firing of action potentials in NG108-15 neuronal cells: Experimental and theoretical studies. J Theor Biol 2008;252:711-21
|
|
|
|
|
|
|
|
|
|
|