Pathological mechanism

Data

Name Amyloid plaques increase elimination of dendritic spines

Description

Hypothesis Dendritic Spine Hypothesis Show Other

Extracelular pathological element Amyloid plaques Show Other

Intracelular pathological element

Pathological action Increases Show Other

Process Dendritic Spine Loss Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region

Neuron

Cell model Brain slice preparations Show Other

Cellular compartment Dendrite Show Other

PubMed ID 17717139

Citation

AlzWeb

Notes Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model.Spires-Jones TL, Meyer-Luehmann M, Osetek JD, Jones PB, Stern EA, Bacskai BJ, Hyman BT.Am J Pathol. 2007 Oct;171(4):1304-11. In control animals, spine formation and elimination were equivalent over 1 hour of observation ( approximately 5% of observed spines), resulting in stable spine density. However, in aged Tg2576 mice spine elimination increased, specifically in the immediate vicinity of plaques. Spine formation was unchanged, resulting in spine loss.

Pathology

Stage

Question

Claim Loss/alteration of dendritic spines in early Alzheimer's Show Other