Pathological mechanism
Amyloid plaques increase elimination of dendritic spines
Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model.Spires-Jones TL, Meyer-Luehmann M, Osetek JD, Jones PB, Stern EA, Bacskai BJ, Hyman BT.Am J Pathol. 2007 Oct;171(4):1304-11. In control animals, spine formation and elimination were equivalent over 1 hour of observation ( approximately 5% of observed spines), resulting in stable spine density. However, in aged Tg2576 mice spine elimination increased, specifically in the immediate vicinity of plaques. Spine formation was unchanged, resulting in spine loss.
  • Loss/alteration of dendritic spines in early Alzheimer's Show Other
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Last Time: 6/16/2008 1:41:58 PM
Reviewer: Pradeep Mutalik
Owner: Pradeep Mutalik