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Pathological mechanism
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Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e
  • Hippocampus CA1 pyramidal GLU cell Show Other
Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons.Shrestha BR, Vitolo OV, Joshi P, Lordkipanidze T, Shelanski M, Dunaevsky A. Mol Cell Neurosci. 2006 Nov;33(3):274-82. Exposure of hippocampal neurons to sub-lethal levels of Abeta decreased spine density, increased spine length and subdued spine motility. The effect of Abeta on spine density was reversible. Moreover, Abeta's effect on dendritic spine density was blocked by rolipram, a phosphodiesterase type IV inhibitor.
  • Loss/alteration of dendritic spines in early Alzheimer's Show Other
Other categories referring to Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e
Revisions: 1
Last Time: 6/17/2008 11:57:58 AM
Reviewer: Pradeep Mutalik
Owner: Pradeep Mutalik