Pathological mechanism

Data

Name Abeta decreases p-21 activated kinase and causes cofilin pathology

Description

Hypothesis Dendritic Spine Hypothesis Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element p-21 activated kinase (PAK) Show Other

Pathological action

Process

Process action Decreases Show Other

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region

Neuron

Cell model

Cellular compartment Dendrite Show Other

PubMed ID 16415866

Citation

AlzWeb

Notes Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.Zhao L, Ma QL, Calon F, Harris-White ME, Yang F, Lim GP, Morihara T, Ubeda OJ, Ambegaokar S, Hansen JE, Weisbart RH, Teter B, Frautschy SA, Cole GM. Nat Neurosci. 2006 Feb;9(2):234-42. Beta-amyloid (Abeta) was directly involved in PAK signaling deficits and drebrin loss in Abeta oligomer-treated hippocampal neurons and in the Appswe transgenic mouse. Pharmacological PAK inhibition in adult mice was sufficient to cause similar cofilin pathology, drebrin loss and memory impairment.

Pathology Alzheimer Show Other

Stage Early Show Other

Question Exclude -biochemistry

Claim