Pathological mechanism

Data

Name Drebrin decrease causes cognitive deficits but does not affest spatial memory

Description

Hypothesis Dendritic Spine Hypothesis Show Other

Extracelular pathological element Drebrin Show Other

Intracelular pathological element

Pathological action Is Inversely Correlated with Show Other

Process Cognitive Decline in Alzheimer's Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region

Neuron

Cell model

Cellular compartment

PubMed ID

Citation

AlzWeb

Notes Antisense knockdown of drebrin A, a dendritic spine protein, causes stronger preference, impaired pre-pulse inhibition, and an increased sensitivity to psychostimulant.Kobayashi R, Sekino Y, Shirao T, Tanaka S, Ogura T, Inada K, Saji M. Neurosci Res. 2004 Jun;49(2):205-17. Rats with drebrin A in vivo knockdown displayed a stronger preference for a previous event due to perseverative behavior, impaired pre-pulse inhibition (PPI), increased locomotor activity, anxiety-like behavior, and an increased sensitivity to psychostimulant, suggesting behaviors related to schizophrenia. These findings indicated that decreased drebrin produces deficits in cognitive function but not in spatial memory.

Pathology

Stage

Question Exclude -behavior, no electrophysiology

Claim