Pathological mechanism

Data

Name Apolipoprotein E4 (Apo E4) levels are inversely correlated with dendritic spine density

Description

Hypothesis Dendritic Spine Hypothesis Show Other

Extracelular pathological element

Intracelular pathological element Apolipoprotein E4 (Apo E4) Show Other

Pathological action Is Inversely Correlated with Show Other

Process Dendritic spine density Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region Hippocampus CA1 Show Other

Neuron Dentate gyrus granule GLU cell Show Other

Cell model Human Post-mortem Study Show Other

Cellular compartment

PubMed ID 14614898

Citation

AlzWeb

Notes Ji, Y., Gong, Y., Gan, W., Beach, T., Holtzman, D. M., & Wisniewski, T. (2003). Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and alzheimer's disease patients. Neuroscience, 122(2), 305-315. Human apoE3 and WT mice had a higher density of dendritic spines than human E4 and apoE KO mice in the 1 and 2 year age groups. In human brain, apoE4 dose correlated inversely with dendritic spine density of DG neurons cell in the hippocampus of both AD (P=0.0008) and aged normal controls (P=0.0015).

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim Loss/alteration of dendritic spines in early Alzheimer's Show Other