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Pathological mechanism
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NGF restores dendritic spine density in Layer V pyramidal neurons
  • Neocortex V1 L6 pyramidal corticothalamic cell Show Other
  • Golgi impregnation - Animal post-mortem brains Show Other
Mervis, R. F., Pope, D., Lewis, R., Dvorak, R. M., & Williams, L. R. (1991). Exogenous nerve growth factor reverses age-related structural changes in neocortical neurons in the aging rat. A quantitative golgi study. Annals of the New York Academy of Sciences, 640, 95-101. NGF treatment restored dendritic spine densities to those seen in young controls on terminal tip segments ("plastic" regions). Internal branch segments ("nonplastic" regions) showed no response to NGF.
  • Loss/alteration of dendritic spines in early Alzheimer's Show Other
Other categories referring to NGF restores dendritic spine density in Layer V pyramidal neurons
Revisions: 2
Last Time: 6/17/2008 1:50:33 PM
Reviewer: Pradeep Mutalik
Owner: Pradeep Mutalik