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Pathological mechanism
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Galantamine increases dopamine release in the hippocampus
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The allosteric potentiation of nicotinic acetylcholine receptors by galantamine ameliorates the cognitive dysfunction in beta amyloid25-35 i.c.v.-injected mice: involvement of dopaminergic systems.Wang D, Noda Y, Zhou Y, Mouri A, Mizoguchi H, Nitta A, Chen W, Nabeshima T. Neuropsychopharmacology. 2007 Jun;32(6):1261-71. Galantamine augments dopaminergic neurotransmission within the hippocampus through the allosteric potentiation of nAChRs. The improving-effects of galantamine on the Abeta(25-35)-induced cognitive impairment may be mediated through the activation of, at least in part, dopaminergic systems
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Revisions: 3
Last Time: 6/27/2008 2:43:16 PM
Reviewer: Pradeep Mutalik
Owner: Pradeep Mutalik