Pathological mechanism
Nicotine increases APP and APLP2 gene expression
Nicotine treatment facilitates the increase in the expression of mRNA and protein of the APP and APLP2 genes in rat brain (hippocampus and amygdala) and SH-SY5Y neuroblastoma cells. Co-treatment with mecamylamine (an antagonist of nicotinic acetylcholine receptors) attenuated the stimulating effect of nicotine on APP and APLP2 expression.Nicotine modulates expression of amyloid precursor protein and amyloid precursor-like protein 2 in mouse brain and in SH-SY5Y neuroblastoma cells.Gutala R, Wang J, Hwang YY, Haq R, Li MD. Brain Res. 2006 Jun 6;1093(1):12-9.
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Last Time: 10/27/2017 10:04:38 PM
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Owner: Pradeep Mutalik