Pathological mechanism
Memantine reduces APP, Galantamine and Nicotine increase synaptophysin
  • Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. Show Other
Effect of subchronic treatment of memantine, galantamine, and nicotine in the brain of Tg2576 (APPswe) transgenic mice.Unger C, Svedberg MM, Yu WF, Hedberg MM, Nordberg A. J Pharmacol Exp Ther. 2006 Apr;317(1):30-6. Memantine treatment reduced the total cortical levels of membrane-bound amyloid precursor protein (45-55%) in both transgenic and nontransgenic mice, which eventually may decrease the level of Abeta.Treatment with nicotine also resulted in less glial fibrillary acidic protein immunoreactive astrocytes around the plaques, increased levels of synaptophysin, and increased number of alpha7 nicotinic acetylcholine receptors (nAChRs) in the cortex of APPswe transgenic mice. Galantamine treatment caused an increase in the cortical levels of synaptophysin in the APPswe mice.
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Last Time: 10/27/2017 10:01:10 PM
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