Pathological mechanism

Data

Name Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine.

Description

Hypothesis Nicotinic Receptor Hypothesis Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Antagonizes Show Other

Process

Process action

Transmitter(s)

Receptor(s) Cholinergic Receptors Show Other Nicotinic Show Other

Channel(s)

Pharmacological Agent Acetyl Choline Show Other Choline Show Other Nicotine Show Other

Pharmacological Action Opposes Show Other

Brain region Hippocampus CA1 Show Other

Neuron

Cell model Brain slice preparations Show Other

Cellular compartment

PubMed ID 16303255

Citation

AlzWeb

Notes Spencer, J. P., Weil, A., Hill, K., Hussain, I., Richardson, J. C., Cusdin, F. S., et al. (2006). Transgenic mice over-expressing human beta-amyloid have functional nicotinic alpha 7 receptors. Neuroscience, 137(3), 795-805. Amyloid beta peptide(1-42) antagonized human alpha7 responses in a partially reversible fashion; no agonist effects were detected. A similar inhibition of mouse alpha 7 was also observed. Hippocampal GABAergic interneurones in slices from beta-amyloid over-expressing mice still possess alpha 7 receptor-mediated currents.

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim