Pathological mechanism

Data

Name Alpha4beta2 receptor blockade causes memory impairment

Description

Hypothesis Nicotinic Receptor Hypothesis Show Other

Extracelular pathological element Dihydro-beta-erythroidine (DHbetaE) Show Other

Intracelular pathological element

Pathological action Induces Show Other

Process memory and learning deficits Show Other

Process action Blocks Show Other

Transmitter(s)

Receptor(s) Cholinergic Receptors Show Other Nicotinic Show Other

Channel(s)

Pharmacological Agent Clozapine Show Other

Pharmacological Action Reverses Show Other

Brain region Hippocampus CA1 Show Other

Neuron

Cell model Brain slice preparations Show Other

Cellular compartment

PubMed ID 16715255

Citation

AlzWeb

Notes Pocivavsek, A., Icenogle, L., & Levin, E. D. (2006). Ventral hippocampal alpha7 and alpha4beta2 nicotinic receptor blockade and clozapine effects on memory in female rats. Psychopharmacology, 188(4), 597-604. The state of nicotinic receptor activation in the ventral hippocampus significantly affected the impact of clozapine on working memory with blockade of alpha7 nicotinic receptors potentiating clozapine-induced memory impairment and blockade of alpha4beta2 receptors reversing the clozapine effect from impairing to improving memory.

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim