Pathological mechanism
Alpha4beta2 receptor blockade causes memory impairment
  • Dihydro-beta-erythroidine (DHbetaE) Show Other
Pocivavsek, A., Icenogle, L., & Levin, E. D. (2006). Ventral hippocampal alpha7 and alpha4beta2 nicotinic receptor blockade and clozapine effects on memory in female rats. Psychopharmacology, 188(4), 597-604. The state of nicotinic receptor activation in the ventral hippocampus significantly affected the impact of clozapine on working memory with blockade of alpha7 nicotinic receptors potentiating clozapine-induced memory impairment and blockade of alpha4beta2 receptors reversing the clozapine effect from impairing to improving memory.
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Last Time: 11/21/2008 12:49:14 PM
Reviewer: Pradeep Mutalik
Owner: Pradeep Mutalik