Pathological mechanism

Data

Name Abeta causes selective neuronal mortality. This requires cell membrane binding.

Description

Hypothesis Neuronal Death Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Increases Show Other

Process Increased Neuronal Mortality Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region Hippocampus CA1 Show Other Visual cortex Show Other

Neuron

Cell model Cultured cortical neurons Show Other

Cellular compartment

PubMed ID 18077683

Citation

AlzWeb

Notes Simakova, O., & Arispe, N. J. (2007). The cell-selective neurotoxicity of the alzheimer's abeta peptide is determined by surface phosphatidylserine and cytosolic ATP levels. Membrane binding is required for abeta toxicity. J Neurosci, 27(50), 13719-13729. The response to Abeta by the cells with high Abeta binding affinity was characterized by a larger calcium response and increased mortality, lactate dehydrogenase release, caspase activation, and DNA fragmentation. This selective Abeta binding was correlated to distinctive cell characteristics, such as cell membrane exposure of the apoptotic signal molecule phosphatidyl serine, larger cell size, the G1 cell cycle stage, and a lower than normal cytosolic ATP level.

Pathology Alzheimer Show Other

Stage Late Show Other

Question Exclude -Neurotoxicity

Claim