Synaptic Abeta and p-tau fluorescence was significantly correlated (r = 0.683, P < 0.004), and dual-labeling experiments demonstrated that 24.1% of Abeta-positive terminals were also positive for p-tau, with the highest fraction of dual labeling (39.3%) in the earliest affected region, the entorhinal cortex in synaptosomes prepared from AD brains.
Fein, J. A., Sokolow, S., Miller, C. A., Vinters, H. V., Yang, F., Cole, G. M., et al. (2008). Co-Localization of amyloid beta and tau pathology in alzheimer's disease synaptosomes. The American Journal of Pathology, 172(6), 1683-1692.