Pathological mechanism

Data

Name Abeta blocks voltage-gated Na+ channels in GABA neurons causing abberant excitation

Description

Hypothesis Dendritic hypothesis Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action

Process

Process action Blocks Show Other

Transmitter(s)

Receptor(s)

Channel(s) I Sodium Show Other

Pharmacological Agent

Pharmacological Action

Brain region Hippocampus CA1 Show Other Visual cortex Show Other

Neuron

Cell model Brain slice preparations Show Other

Cellular compartment

PubMed ID

Citation

AlzWeb

Notes Abeta blocks voltage-gated Na+ channels in GABA neurons causing abberant excitation in hAPP transgenic mice, that have cognitive deficits similar to AD. This seizure-like activity may lead to inhibitory mechanisms that produce cognitive deficits. Alzheimer's and Dementia Supplement, 2008 (ICAD meeting). Palop JJ, Thwin, Ho, Yu and Mucke

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim