Pathological mechanism

Data

Name Memory loss caused by beta-amyloid protein is rescued by a beta(3)-adrenoceptor agonist

Description

Hypothesis

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action

Process

Process action Blocks Show Other

Transmitter(s)

Receptor(s) Adrenergic Show Other Beta Show Other

Channel(s)

Pharmacological Agent CL316243 Show Other

Pharmacological Action Reverses Show Other

Brain region

Neuron

Cell model Behavioral study Show Other

Cellular compartment

PubMed ID

Citation

AlzWeb

Notes A beta(3)-AR agonist (CL316243), but not a beta(2)-AR agonist, rescued Abeta-induced memory loss in chicks given an intra-cranial injection of Abeta42. Memory loss caused by beta-amyloid protein is rescued by a beta(3)-adrenoceptor agonist.Gibbs ME, Maksel D, Gibbs Z, Hou X, Summers RJ, Small DH. Neurobiol Aging. 2008 Jul 14

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim