Pathological mechanism

Data

Name Abeta-derived diffusible ligands (ADDLs) attack synapses at or near NMDA receptors

Description

Hypothesis

Extracelular pathological element Abeta-derived diffusible ligands (ADDLs) Show Other

Intracelular pathological element

Pathological action Induces Show Other

Process Synapse Loss Show Other

Process action Binds at or near Show Other

Transmitter(s)

Receptor(s) NMDA Show Other

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region

Neuron

Cell model

Cellular compartment

PubMed ID 18165846

Citation

AlzWeb

Notes ADDL binding instigates synapse loss, oxidative damage, and AD-type tau hyperphosphorylation.ADDLs act as pathogenic gain-of-function ligands that target particular synapses, binding to synaptic spines at or near NMDA receptors. Subsequent ADDL-induced abnormalities in spine morphology and synaptic receptor composition. Viola, K. L., Velasco, P. T., & Klein, W. L. (2008). Why alzheimer's is a disease of memory: The attack on synapses by A beta oligomers (addls). The Journal of Nutrition, Health & Aging, 12(1), 51S-57S.

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim