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Pathological mechanism
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Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro.
The addition of Abeta1-42 to cortical or hippocampal neurons reduced the amounts of cell associated synaptophysin, a pre-synaptic membrane protein that is essential for neurotransmission, indicating synapse damage. The effects of Abeta1-42 on synapses were apparent at concentrations approximately 100 fold less than that required to kill neurons; the synaptophysin content of neuronal cultures was reduced by 50% by 50 nM Abeta1-42. Pre-treatment of cortical or hippocampal neuronal cultures with ginkgolides A or B, but not with myrecitin or quercetin, protected against Abeta1-42-induced loss of synaptophysin. Bate, C., Tayebi, M., & Williams, A. (2008). Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro. Molecular Neurodegeneration, 3, 1.
Exclude - dietary factors, no electrophysiology
Other categories referring to Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro.
Revisions: 4
Last Time: 10/27/2017 10:05:55 PM
Reviewer: System Administrator
Owner: Pradeep Mutalik