Pathological mechanism

Data

Name Aging causes reduction in dendrite complexity, spine loss, decreased glutamate, increased GABA

Description

Hypothesis Synapse Loss Show Other

Extracelular pathological element

Intracelular pathological element

Pathological action Is Correlated with Show Other

Process Aging Show Other

Process action Decreases Show Other

Transmitter(s) Glutamate Show Other

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region

Neuron

Cell model

Cellular compartment

PubMed ID 17465981

Citation

AlzWeb

Notes During aging, neurons undergo morphological changes such as a reduction in the complexity of dendrite arborization and dendritic length. Spine numbers are also decreased, and this could reflect a change in synaptic densities. There is a decrease in the overall frequency of spontaneous glutamate receptor-mediated excitatory responses, and in the levels of AMPA and NMDA receptor expression. Gamma-aminobutyric acid A receptor-mediated inhibitory responses and action potential firing rates are both significantly increased with age. Dickstein, D. L., Kabaso, D., Rocher, A. B., Luebke, J. I., Wearne, S. L., & Hof, P. R. (2007). Changes in the structural complexity of the aged brain. Aging Cell, 6(3), 275-284.

Pathology Alzheimer Show Other

Stage Early Show Other

Question Exclude - Aging alone, no electrophysiology

Claim