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Globus pallidus multi-compartmental model neuron with realistic morphology (Gunay et al. 2008)
"Globus pallidus (GP) neurons recorded in brain slices show significant variability in intrinsic electrophysiological properties. To investigate how this variability arises, we manipulated the biophysical properties of GP neurons using computer simulations. ... Our results indicated that most of the experimental variability could be matched by varying conductance densities, which we confirmed with additional partial block experiments. Further analysis resulted in two key observations: (1) each voltage-gated conductance had effects on multiple measures such as action potential waveform and spontaneous or stimulated spike rates; and (2) the effect of each conductance was highly dependent on the background context of other conductances present. In some cases, such interactions could reverse the effect of the density of one conductance on important excitability measures. ..."
  • Neuron or other electrically excitable cell Show Other
  • Günay C, Edgerton JR, Jaeger D (2008) Show Other
cgunay@emory.edu
Kv2, Kv3
Gunay, Cengiz <cgunay@emory.edu> Edgerton, Jeremy R. <jedgert@emory.edu> Hanson, Jesse E.
18650326
False
False
Other categories referring to Globus pallidus multi-compartmental model neuron with realistic morphology (Gunay et al. 2008)
Revisions: 6
Last Time: 8/16/2008 6:55:20 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin