Pathological mechanism
BACE1 required for LTP at mossy fiber-CA3 synapses
  • Hippocampus CA3 pyramidal GLU cell Show Other
BACE1 knock-out mice display reduced presynaptic function at the mossy fiber projections in CA3. Mossy fiber long-term potentiation (LTP), which is normally expressed via an increase in presynaptic release, was eliminated in the knock-outs. The specific deficit in mossy fiber LTP was upstream of cAMP signaling and could be "rescued" by transiently elevating extracellular Ca2+ concentration. These results suggest that BACE1 may play a critical role in regulating presynaptic function, especially activity-dependent strengthening of presynaptic release, at mossy fiber synapses. BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus.Wang H, Song L, Laird F, Wong PC, Lee HK. J Neurosci. 2008 Aug 27;28(35):8677-81.
Other categories referring to BACE1 required for LTP at mossy fiber-CA3 synapses
Revisions: 4
Last Time: 9/5/2008 12:41:16 PM
Reviewer: Pradeep Mutalik
Owner: Pradeep Mutalik