Pathological mechanism

Data

Name Histidine associating compounds block Abeta Channel activity and cytotoxicity

Description

Hypothesis Abeta Channel Hypothesis Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Induces Show Other

Process Cytotoxicity Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent Histidine-associating Compounds Show Other

Pharmacological Action Blocks Show Other

Brain region

Neuron

Cell model

Cellular compartment

PubMed ID 18723589

Citation

AlzWeb

Notes The opening of the Alzheimer's Abeta channel permits the flux of calcium into the cell, thus critically disturbing intracellular ion homeostasis. Peptide segments which include the characteristic histidine diad, His13 and His14, efficiently block the Abeta channel activity blocking Abeta cytotoxicity. Compounds that are known to have histidine association capacity, such as Ni(2+), imidazole, histidine and a series of histidine-related compounds were effective at blocking both Abeta channels and preventing Abeta cytotoxicity. The efficiency of protection of histidine-related compounds was correlated with the number of imidazole side chains in the blocker compounds. Efficiency of histidine-associating compounds for blocking the Alzheimer's A{beta} channel activity and cytotoxicity.Arispe NJ, Diaz JC, Flora M. Biophys J. 2008 Aug 22.

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim