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Axonal NaV1.6 Sodium Channels in AP Initiation of CA1 Pyramidal Neurons (Royeck et al. 2008)
"... We show that the Na+ channel NaV1.6 displays a striking aggregation at the AIS of cortical neurons. ... In combination with simulations using a realistic computer model of a CA1 pyramidal cell, our results imply that a hyperpolarized voltage-dependence of activation of AIS NaV1.6 channels is important both in determining spike threshold and localizing spike initiation to the AIS. ... These results suggest that NaV1.6 subunits at the AIS contribute significantly to its role as spike trigger zone and shape repetitive discharge properties of CA1 neurons."
  • Hippocampus CA1 pyramidal GLU cell Show Other
  • Neuron or other electrically excitable cell Show Other
  • Royeck M, Horstmann MT, Remy S, Reitze M, Yaari Y, Beck H (2008) Show Other
  • Horstmann, Marie-Therese [mhorstma at uni-bonn.de] Show Other
tom.morse@yale.edu
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Other categories referring to Axonal NaV1.6 Sodium Channels in AP Initiation of CA1 Pyramidal Neurons (Royeck et al. 2008)
Revisions: 12
Last Time: 1/20/2014 3:55:02 PM
Reviewer: Robert A McDougal
Owner: Tom Morse - MoldelDB admin