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Data
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Pyramidal neurons switch from integrators to resonators (Prescott et al. 2008)
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During wakefulness, pyramidal neurons in the intact brain are bombarded by synaptic
input that causes tonic depolarization, increased membrane conductance (i.e. shunting), and
noisy fluctuations in membrane potential; by comparison, pyramidal neurons in acute slices
typically experience little background input.
Such differences in operating conditions can compromise extrapolation of in vitro data to explain
neuronal operation in vivo.
...
in slice experiments, we show that
CA1 hippocampal pyramidal cells switch from integrators to resonators, i.e. from class 1 to class
2 excitability.
The switch is explained by increased outward current contributed by the M-type
potassium current IM
...
Thus, even so-called “intrinsic” properties may differ qualitatively between in vitro and in vivo conditions.
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Neuron or other electrically excitable cell Show
Other
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Prescott SA, Ratté S, De Koninck Y, Sejnowski TJ (2008) Show
Other
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Prescott, Steven [steve.prescott at sickkids.ca]] Show
Other
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