Computational model
Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
"Biophysical properties of neurons contributing to the ability of an animal to decide whether or not to respond were examined. B31/B32, two pairs of bilaterally symmetrical Aplysia neurons, are major participants in deciding to initiate a buccal motor program, the neural correlate of a consummatory feeding response. B31/B32 respond to an adequate stimulus after a delay, during which time additional stimuli influence the decision to respond. B31/B32 then respond with a ramp depolarization followed by a sustained soma depolarization and axon spiking that is the expression of a commitment to respond to food. Four currents contributing to decision making in B31/B32 were characterized, and their functional effects were determined, in current- and voltage-clamp experiments and with simulations. ... Hodgkin-Huxley kinetic analyses were performed on the outward currents. Simulations using equations from these analyses showed that IK-V and IK-A slow the ramp depolarization preceding the sustained depolarization. The three outward currents contribute to braking the B31/B32 depolarization and keeping the sustained depolarization at a constant voltage. The currents identified are sufficient to explain the properties of B31/B32 that play a role in generating the decision to feed."
  • Neuron or other electrically excitable cell Show Other
  • Action Selection/Decision Making Show Other
  • Hurwitz I, Ophir A, Korngreen A, Koester J, Susswein AJ (2008) Show Other
J Neurophysiol 99:814-30
Other categories referring to Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)
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Last Time: 2/26/2019 10:08:25 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin