BrainPharm: Computational model - Multicompartmental cerebellar granule cell model (Diwakar et al. 2009)

Computational model

Data

Name

Multicompartmental cerebellar granule cell model (Diwakar et al. 2009)

Submitter name

Pipeline ID

Model File

GrC [1706726]

Notes

A detailed multicompartmental model was used to study neuronal electroresponsiveness of cerebellar granule cells in rats. Here we show that, in cerebellar granule cells, Na+ channels are enriched in the axon, especially in the hillock, but almost absent from soma and dendrites. Numerical simulations indicated that granule cells have a compact electrotonic structure allowing EPSPs to diffuse with little attenuation from dendrites to axon. The spike arose almost simultaneously along the whole axonal ascending branch and invaded the hillock, whose activation promoted spike back-propagation with marginal delay (<200 micros) and attenuation (<20 mV) into the somato-dendritic compartment. For details check the cited article.

Model Neurons

Cerebellum interneuron granule GLU cell Show Other

More Cells

Model Currents

I A Show Other
I M Show Other
I h Show Other
I K,Ca Show Other
I Sodium Show Other
I Calcium Show Other
I Potassium Show Other
I A, slow Show Other

Model Receptors

Model Type

Neuron or other electrically excitable cell Show Other

Model Concept

Action Potential Initiation Show Other
Active Dendrites Show Other
Detailed Neuronal Models Show Other
Axonal Action Potentials Show Other
Action Potentials Show Other
Intrinsic plasticity Show Other

Simulator software

NEURON Show Other

Model papers

Diwakar S, Magistretti J, Goldfarb M, Naldi G, D'Angelo E (2009) Show Other

Gene

hg folder name (applicable when in ModelDB hg)

116835

Region Organism

Cerebellum Show Other

Model ID Number

Gap Junctions

Implemented by

Diwakar, Shyam [shyam at amrita.edu] Show Other

Public Submitter Email Address

Other Neuron

Model Neurotransmitters

Other Receptor

Other Current

Other Neurotransmitter

Other Model Type

Other Concept

Other Simulator

Other Implementer

Diwakar, Shyam shyam@unipv.it

Alternative Version

Citation

Default File Notes

Other Gene

Simulation Platform ID

287

Has Model View

True

Component

RAM

Hide Auto-launch button

False

Run Protocols

116835 Show Other

ICG Channel Details

Species

Other categories referring to Multicompartmental cerebellar granule cell model (Diwakar et al. 2009)

Revisions:	14
Last Time:	11/4/2022 12:59:59 PM
Reviewer:	System Administrator
Owner:	Tom Morse - MoldelDB admin