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Data
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Rat alpha7 nAChR desensitization is modulated by W55 (Gay et al. 2008)
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"The rat alpha7 nicotinic acetylcholine receptor (nAChR) can undergo rapid onset of desensitization; however, the mechanisms of desensitization are largely unknown.
The contribution of a tryptophan (W) residue at position 55 of the rat alpha7 nAChR subunit, which lies within the beta2 strand, was studied by mutating it to other hydrophobic and/or aromatic amino acids, followed by voltage-clamp experiments in Xenopus oocytes.
When mutated to alanine, the alpha7-W55A nAChR desensitized more slowly, and recovered from desensitization more rapidly, than wildtype alpha7 nAChRs.
The contribution of desensitization was validated by kinetic modelling. ..."
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Gay EA, Giniatullin R, Skorinkin A, Yakel JL (2008) Show
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Skorinkin, Andrei [askorink at yandex.ru] Show
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tom.morse@yale.edu
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