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Data
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Stochastic automata network Markov model descriptors of coupled Ca2+ channels (Nguyen et al. 2005)
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"... Here we present a formalism by which mathematical models for Ca2+-regulated Ca2+ release sites
are derived from stochastic models of single-channel gating that include Ca2+ activation, Ca2+
inactivation, or both.
Such models are stochastic automata networks (SANs) that involve a large
number of functional transitions, that is, the transition probabilities of the infinitesimal generator
matrix of one of the automata (i.e., an individual channel) may depend on the local [Ca2+] and
thus the state of the other channels. Simulation and analysis of the SAN descriptors representing
homogeneous clusters of intracellular Ca2+ channels show that (1) release site density can modify
both the steady-state open probability and stochastic excitability of Ca2+ release sites, (2) Ca2+
inactivation is not a requirement for Ca2+ puffs or sparks, and (3) a single-channel model with a
bell-shaped open probability curve does not lead to release site activity that is a biphasic function of
release site density.
..."
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CalC Calcium Calculator (web link to model) Show
Other
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Nguyen V, Mathias R, Smith GD (2005) Show
Other
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Matveev, Victor V. [m a t v e e v at n j i t . e d u ] Show
Other
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