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CA1 pyramidal neurons: effects of a Kv7.2 mutation (Miceli et al. 2009)
mutant [?]
NEURON mod files from the paper: Miceli et al, Neutralization of a unique, negatively-charged residue in the voltage sensor of K(V)7.2 subunits in a sporadic case of benign familial neonatal seizures, Neurobiol Dis., in press (2009). In this paper, the model revealed that the gating changes introduced by a mutation in K(v)7.2 genes encoding for the neuronal KM current in a case of benign familial neonatal seizures, increased cell firing frequency, thereby triggering the neuronal hyperexcitability which underlies the observed neonatal epileptic condition.
  • Hippocampus CA1 pyramidal GLU cell Show Other
  • Miceli F, Soldovieri MV, Lugli L, Bellini G, Ambrosino P, Migliore M, del Giudice EM, Ferrari F, Pascotto A, Taglialatela M (2009) Show Other
  • Migliore, Michele [Michele.Migliore at Yale.edu] Show Other
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Revisions: 6
Last Time: 2/6/2014 4:14:47 PM
Reviewer: Robert A McDougal
Owner: Tom Morse - MoldelDB admin