Computational model
TTX-R Na+ current effect on cell response (Herzog et al 2001) (MATLAB)
"Small dorsal root ganglion (DRG) neurons, which include nociceptors, express multiple voltage-gated sodium currents. In addition to a classical fast inactivating tetrodotoxin-sensitive (TTX-S) sodium current, many of these cells express a TTX-resistant (TTX-R) sodium current that activates near -70 mV and is persistent at negative potentials. To investigate the possible contributions of this TTX-R persistent (TTX-RP) current to neuronal excitability, we carried out computer simulations using the Neuron program with TTX-S and -RP currents, fit by the Hodgkin-Huxley model, that closely matched the currents recorded from small DRG neurons. ..." See paper for more and details.
  • Neuron or other electrically excitable cell Show Other
  • Herzog RI, Cummins TR, Waxman SG (2001) Show Other
  • Andersson, Thomas [toma at] Show Other
Other categories referring to TTX-R Na+ current effect on cell response (Herzog et al 2001) (MATLAB)
Revisions: 10
Last Time: 4/29/2009 11:36:02 AM
Owner: Tom Morse - MoldelDB admin