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A kinetic model unifying presynaptic short-term facilitation and depression (Lee et al. 2009)
"... Here, we propose a unified theory of synaptic short-term plasticity based on realistic yet tractable and testable model descriptions of the underlying intracellular biochemical processes. Analysis of the model equations leads to a closed-form solution of the resonance frequency, a function of several critical biophysical parameters, as the single key indicator of the propensity for synaptic facilitation or depression under repetitive stimuli. This integrative model is supported by a broad range of transient and frequency response experimental data including those from facilitating, depressing or mixed-mode synapses. ... the model provides the reasons behind the switching behavior between facilitation and depression observed in experiments. ..."
  • Lee CC, Anton M, Poon CS, McRae GJ (2009) Show Other
  • Lee, Chuang-Chung [chchlee at alum.mit.edu] Show Other
  • Anton, Mihai [mianton at mit.edu] Show Other
  • Poon, Chi-Sang [cpoon at mit.edu] Show Other
  • McRae, Gregory [mcrae at mit.edu] Show Other
chchlee@alum.mit.edu
Lee, Chuang-Chung <chchlee@alum.mit.edu> Anton, Mihai <mianton@mit.edu> Poon, Chi-Sang <cpoon@mit.edu> McRae, Gregory <mcrae@mit.edu>
Lee, C.-C., Anton, M., Poon, C.-S., and McRae G. J. (2009) ¡§The Unified Theory of Homosynaptic Short Term Depression and Facilitation¡¨, J. Comut. Neurosci, 26(3):459-473.
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Revisions: 9
Last Time: 5/8/2009 4:20:37 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin