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A model of beta-adrenergic modulation of IKs in the guinea-pig ventricle (Severi et al. 2009)
Detailed understanding of IKs gating complexity may provide clues on the mechanisms of cardiac repolarization instability and the resulting arrhythmias. We developed and tested a kinetic Markov model to interpret physiologically relevant IKs properties, including pause-dependency and modulation by beta-adrenergic receptors (beta-AR). The model was developed from the Silva & Rudy formulation. Parameters were optimized on control and ISO experimental data, respectively.
  • Severi S, Corsi C, Rocchetti M, Zaza A (2009) Show Other
  • Severi, Stefano [stefano.severi at unibo.it] Show Other
stefano.severi@unibo.it
Severi, Stefano <stefano.severi@unibo.it>
19413992
False
False
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Revisions: 7
Last Time: 2/26/2018 11:20:46 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin