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A model of beta-adrenergic modulation of IKs in the guinea-pig ventricle (Severi et al. 2009)
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Detailed understanding of IKs gating complexity may provide clues on the mechanisms of cardiac repolarization instability and the resulting arrhythmias. We developed and tested a kinetic Markov model to interpret physiologically relevant IKs properties, including pause-dependency and modulation by beta-adrenergic receptors (beta-AR). The model was developed from the Silva & Rudy formulation. Parameters were optimized on control and ISO experimental data, respectively.
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Severi S, Corsi C, Rocchetti M, Zaza A (2009) Show
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Severi, Stefano [stefano.severi at unibo.it] Show
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stefano.severi@unibo.it
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Severi, Stefano <stefano.severi@unibo.it>
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