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Mechanisms of very fast oscillations in axon networks coupled by gap junctions (Munro, Borgers 2010)
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Axons connected by gap junctions can produce very fast oscillations (VFOs, > 80 Hz) when stimulated randomly at a low rate. The models here explore the mechanisms of VFOs that can be seen in an axonal plexus, (Munro & Borgers, 2009): a large network model of an axonal plexus, small network models of axons connected by gap junctions, and an implementation of the model underlying figure 12 in Traub et al. (1999) .
The large network model consists of 3,072 5-compartment axons connected in a random network. The 5-compartment axons are the 5 axonal compartments from the CA3 pyramidal cell model in Traub et al. (1994) with a fixed somatic voltage. The random network has the same parameters as the random network in Traub et al. (1999), and axons are stimulated randomly via a Poisson process with a rate of 2/s/axon.
The small network models simulate waves propagating through small networks of axons connected by gap junctions to study how local connectivity affects the refractory period.
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Hippocampus CA3 pyramidal GLU cell Show
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Munro, Erin [ecmun at math.bu.edu] Show
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ecmun2002@yahoo.com
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