
Data

Mechanisms of very fast oscillations in axon networks coupled by gap junctions (Munro, Borgers 2010)




Axons connected by gap junctions can produce very fast oscillations (VFOs, > 80 Hz) when stimulated randomly at a low rate. The models here explore the mechanisms of VFOs that can be seen in an axonal plexus, (Munro & Borgers, 2009): a large network model of an axonal plexus, small network models of axons connected by gap junctions, and an implementation of the model underlying figure 12 in Traub et al. (1999) .
The large network model consists of 3,072 5compartment axons connected in a random network. The 5compartment axons are the 5 axonal compartments from the CA3 pyramidal cell model in Traub et al. (1994) with a fixed somatic voltage. The random network has the same parameters as the random network in Traub et al. (1999), and axons are stimulated randomly via a Poisson process with a rate of 2/s/axon.
The small network models simulate waves propagating through small networks of axons connected by gap junctions to study how local connectivity affects the refractory period.


Hippocampus CA3 pyramidal GLU cell Show
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Munro, Erin [ecmun at math.bu.edu] Show
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ecmun2002@yahoo.com





















