|
|
|
Data
|
Submyelin Potassium accumulation in Subthalamic neuron (STN) axons (Bellinger et al. 2008)
|
|
|
|
|
|
|
"To better understand the direct effects of DBS (Deep brain stimulation) on central neurons, a computational model of a myelinated axon has been constructed which includes the effects of K+ accumulation within the peri-axonal space.
Using best estimates of anatomic and electrogenic model parameters for in vivo STN axons, the model predicts a functional block along the axon due to K+ accumulation in the submyelin space.
...
These results suggest that therapeutic DBS of the STN likely results in a functional block for many STN axons, although a subset of STN axons may also be activated at the stimulating frequency.
"
|
|
|
-
Subthalamus nucleus projection neuron Show
Other
|
|
|
|
|
|
|
|
|
|
|
-
Bellinger SC, Miyazawa G, Steinmetz PN (2008) Show
Other
|
|
|
|
|
|
|
|
|
|
-
Bellinger, Steven [Steve.Bellinger at asu.edu] Show
Other
|
Peter.Steinmetz@chw.edu
|
|
|
|
|
|
|
|
|
|
|
|
|
Depolarization block
|
|
|
Bellinger, Steven
|
|
|
PMID: 18566505 doi:10.1088/1741-2560/5/3/001
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
