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Data
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Action Potential initiation and backpropagation in Neocortical L5 Pyramidal Neuron (Hu et al. 2009)
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"...Previous computational studies have yielded conflicting conclusions
about the role of Na+ channel density and biophysical properties in
action potential initiation as a result of inconsistent estimates of
channel density. Our modeling studies integrated the immunostaining
and electrophysiological results and showed that the lowest
threshold for action potential initiation at the distal AIS was largely
determined by the density of low-threshold Nav1.6 channels ... Distinct from the function of Nav1.6 channel, the Nav1.2 channel
may control action potential backpropagation because of its high
density at the proximal AIS and high threshold. ... In conclusion, distal AIS accumulation of Nav1.6 channels determines
the low threshold for action potential initiation; whereas
proximal AIS accumulation of Nav1.2 channels sets the threshold for
the generation of somatodendritic potentials and ensures action
potential backpropagation to the soma and dendrites. Thus, Nav1.6
and Nav1.2 channels serve distinct functions in action potential
initiation and backpropagation."
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Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell Show
Other
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Neocortex U1 L5B pyramidal pyramidal tract GLU cell Show
Other
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Hu W, Tian C, Li T, Yang M, Hou H, Shu Y (2009) Show
Other
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HuEtAl2009
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hh@ion.ac.cn
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I Nav1.6; I Nav1.2
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Hu, Wenqin <huwenqin@ion.ac.cn>
Hou, Han <hh@ion.ac.cn>
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Hu, W., C. Tian, et al. (2009). "Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation." Nat Neurosci 12(8): 996-1002.
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146
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