BrainPharm: Computational model - Ca2+-activated I_CAN and synaptic depression promotes network-dependent oscil. (Rubin et al. 2009)

Computational model

Data

Name

Ca2+-activated I_CAN and synaptic depression promotes network-dependent oscil. (Rubin et al. 2009)

Submitter name

Pipeline ID

Model File

weblink [1220]

Notes

"... the preBotzinger complex... we present and analyze a mathematical model demonstrating an unconventional mechanism of rhythm generation in which glutamatergic synapses and the short-term depression of excitatory transmission play key rhythmogenic roles. Recurrent synaptic excitation triggers postsynaptic Ca2+- activated nonspecific cation current (ICAN) to initiate a network-wide burst. Robust depolarization due to ICAN also causes voltage-dependent spike inactivation, which diminishes recurrent excitation and thus attenuates postsynaptic Ca2+ accumulation. ..."

Model Neurons

More Cells

PreBotzinger complex neuron Show Other

Model Currents

I CAN Show Other

Model Receptors

AMPA Show Other
mGluR Show Other

Model Type

Realistic Network Show Other
Neuron or other electrically excitable cell Show Other

Model Concept

Bursting Show Other
Oscillations Show Other

Simulator software

C or C++ program (web link to model) Show Other
XPP (web link to model) Show Other
NeuronetExperimenter (web link to model) Show Other

Model papers

Rubin JE, Hayes JA, Mendenhall JL, Del Negro CA (2009) Show Other

Gene

hg folder name (applicable when in ModelDB hg)

Region Organism

Model ID Number

Gap Junctions

Implemented by

Rubin, Jonathan E [jonrubin at pitt.edu] Show Other

Public Submitter Email Address

tom.morse@yale.edu

Other Neuron

Model Neurotransmitters

Other Receptor

Other Current

Other Neurotransmitter

Other Model Type

Other Concept

Other Simulator

Other Implementer

Alternative Version

NeuronetExperimenter demo file Show Other
Neuronet Experimenter simulator file Show Other
Ca2+ activated etc Rubin et al. 2009 XPP file Show Other

Citation

Default File Notes

Other Gene

Simulation Platform ID

Has Model View

False

Component

RAM

Hide Auto-launch button

False

Run Protocols

ICG Channel Details

Species

Other categories referring to Ca2+-activated I_CAN and synaptic depression promotes network-dependent oscil. (Rubin et al. 2009)

Revisions:	8
Last Time:	9/13/2017 5:34:14 PM
Reviewer:	Tom Morse - MoldelDB admin
Owner:	Tom Morse - MoldelDB admin