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Computer model of clonazepam`s effect in thalamic slice (Lytton 1997)
lytton97b_r4 [310249]
Demonstration of the effect of a minor pharmacological synaptic change at the network level. Clonazepam, a benzodiazepine, enhances inhibition but is paradoxically useful for certain types of seizures. This simulation shows how inhibition of inhibitory cells (the RE cells) produces this counter-intuitive effect.
  • Thalamus geniculate nucleus/lateral principal GLU cell Show Other
  • Thalamus reticular nucleus GABA cell Show Other
lytton97b
  • Lytton, William [bill.lytton at downstate.edu] Show Other
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Revisions: 30
Last Time: 6/28/2017 5:25:08 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin