Computational model
CA1 pyramidal neuron: rebound spiking (Ascoli et al.2010)
rebound [?]
The model demonstrates that CA1 pyramidal neurons support rebound spikes mediated by hyperpolarization-activated inward current (Ih), and normally masked by A-type potassium channels (KA). Partial KA reduction confined to one or few branches of the apical tuft may be sufficient to elicit a local spike following a train of synaptic inhibition. These data suggest that the plastic regulation of KA can provide a dynamic switch to unmask post-inhibitory spiking in CA1 pyramidal neurons, further increasing the signal processing power of the CA1 synaptic microcircuitry.
  • Hippocampus CA1 pyramidal GLU cell Show Other
  • Ascoli GA, Gasparini S, Medinilla V, Migliore M (2010) Show Other
  • Migliore, Michele [Michele.Migliore at] Show Other
Other categories referring to CA1 pyramidal neuron: rebound spiking (Ascoli et al.2010)
Revisions: 6
Last Time: 1/2/2015 10:01:01 PM
Reviewer: Robert A McDougal
Owner: Michele Migliore